Clinicopathological Profile of Osteosarcoma Patients in Pathology Department of Saiful Anwar Hospital Malang 2018-2020 Periode

Authors

DOI:

https://doi.org/10.11594/jk-risk.01.3.2

Keywords:

Osteosarcoma, clinicopathology, epidemiology

Abstract

Background: Osteosarcoma is the most common primary bone malignancy. Although the primary tumor has been resected, the patient remains at high risk of metastases. The incidence and clinicopathological characteristics of osteosarcoma need to be studied.

Aim: To obtain epidemiological data that can help in diagnosis and management of osteosarcoma.

Methods: This research was conducted in a retrospective descriptive manner. The data obtained from medical records at the Anatomical Pathology Laboratory, RSU Dr. Saiful Anwar Malang in 2018-2020 which met the inclusion criteria and exclusion criteria. The variables studied included gender, age, location, subtype, grade, Huvos assessment.

Results: There were 68 cases of osteosarcoma that met the criterias. Most of the patients were male (52.94%). The age of the patients was spread from 8 years to 79 years. With average age was 24.56 years, the median age was 16 years, and the most in the age range of 11-25 years. The most common location was the lower extremity (82.35%). The most subtype was osteosarcoma NOS (94.12%). The most cases were high grade (94.12%). From all of cases, 3 cases were huvos graded, 1 case were grade 1, and 2  cases were grade 2.

Conclusion: Most Osteosarcoma patient are men, most often in the age range of 11-25 years. The most common location is in the lower extremities, the most subtype is osteosarcoma NOS, the most grade is High grade. Most of the cases were not carried out by huvos grading.

Downloads

Download data is not yet available.

References

Sadykova LR, Ntekim AI, Muyangwa-Semenova M, et al. Epidemiology and Risk Factors of Osteosarcoma. Cancer Invest. 2020;38(5):259-269. doi:10.1080/07357907.2020.1768401

Prater S, Mckeon B. Cancer , Osteosarcoma. Published online 2020:1-16. https://www.ncbi.nlm.nih.gov/books/NBK549868/

IARC. WHO Classification of Soft Tissue and Bone Tumours. 5TH ed.; 2020. doi:10.1017/CBO9780511545375.031

Wedekind MF, Wagner LM, Cripe TP. Immunotherapy for osteosarcoma: Where do we go from here? Pediatr Blood Cancer. 2018;65(9):1-9. doi:10.1002/pbc.27227

Zhu T, Ye Z. Prognostic role of hypoxia-inducible factor-1 alpha expression in osteosarcoma : a meta-analysis. Published online 2016:1477-1487.

Sui Y, Han Y, Zhao X, Li D, Li G. Long non-coding RNA GClnc1 promotes tumorigenesis in osteosarcoma by inhibiting p53 signaling. Biochem Biophys Res Commun. 2018;507(1-4):36-42. doi:10.1016/j.bbrc.2018.10.135

Mahyudin F, Edward M, Basuki MH, Bari YA, Suwandani Y. Osteosarcoma Has Not Become Attention To Society Profile of Osteosarcoma Patients At Dr. Soetomo General Hospital Surabaya “a Retrospective Study.” J Orthop Traumatol Surabaya. 2019;7(1):20.

doi:10.20473/joints.v7i1.2018.20-30

Vinay Kumar abdul KA. Robbins Basic Pathology, 10th Edition. 10th ed. elsevier; 2018.

Mintaroem K, Prabawati D, Mudjiwiyono, Khasana R. Patologi Umum Dan Pemeriksaan Patologi. 2nd ed. (eviana n rachmad s, ed.).; 2016.

Kim SH, Shin KH, Moon SH, Kong Y, Suh JS, Yang WI. Location of residual viable tumor cells after neoadjuvant chemotherapy: A new concept with high prognostic performance in osteosarcoma. J Surg Oncol. 2017;115(6): 752-759. doi:10.1002/jso.24571

Orell SR. Orell & Sterrett ’ s Fine Needle Aspiration Cytology , Fifth Edition. Published online 2012.

Dabbs DJ. Diagnostic Immunohistochemistry Theranostic and Genomic Applications. Published online 2014.

Valery PC, Laversanne M, Bray F. Bone cancer incidence by morphological subtype: a global assessment. Cancer Causes Control. 2015;26(8):1127-1139. doi:10.1007/s10552-015-0607-3

Yoshida A, Ushiku T, Motoi T, et al. Immunohistochemical analysis of MDM2 and CDK4 distinguishes low-grade osteosarcoma from benign mimics. Mod Pathol. 2010;23(9):1279-1288. doi:10.1038/modpathol.2010.124

Komite Penanggulanan Kanker Nasional. Panduan Penatalaksanaan Osteosarkoma. Kom Penanggulangan Kanker Nas. Published online 2015:1-40.

http://kanker.kemkes.go.id/guidelines/PPKOsteosarkoma.pdf

Downloads

Published

2022-06-17

Issue

Section

Original Article

How to Cite

prihantoro, teguh, Dewi, R., & Norahmawati, E. (2022). Clinicopathological Profile of Osteosarcoma Patients in Pathology Department of Saiful Anwar Hospital Malang 2018-2020 Periode. Jurnal Klinik Dan Riset Kesehatan, 1(3), 147-155. https://doi.org/10.11594/jk-risk.01.3.2