Vascular Awareness as the Key to Limb Salvage in Diabetes Mellitus

Authors

  • Irzal Rakhmadhani Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
  • Novi Kurnianingsih Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
  • Dea Arie Kurniawan Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
  • Veny Mayangsari Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia
  • Rinadhi Reza Bramantya Department of Internal Medicine, Faculty of Medicine Universitas Brawijaya, Malang, East Java, Indonesia
  • Yudi Siswanto Department of Surgery, Faculty of Medicine, Universitas Brawijaya, Dr. Saiful Anwar General Hospital, Malang, East Java, Indonesia

DOI:

https://doi.org/10.11594/jk-risk.06.1.9

Keywords:

CLTI, diabetic foot ulcer, angioplasty, limb salvage

Abstract

Background: Foot ulcers in patients with diabetes mellitus are not always caused by microvascular complications. Some cases represent chronic limb-threatening ischaemia (CLTI), which carries a high risk of major amputation and mortality. Vascular awareness is essential to prevent misdiagnosis and to enable limb salvage strategies.

Case Report: A 54-year-old man with poor health-seeking behavior was newly diagnosed with diabetes mellitus in December 2024 after the appearance of a right foot ulcer. The wound continued to enlarge despite three weeks of treatment, leading to referral to a cardiologist. Evaluation revealed atrial fibrillation and heart failure with reduced ejection fraction (EF 31%). Physical examination showed a cold, pulseless right limb, although motor–sensory function was preserved. Doppler ultrasonography demonstrated complete popliteal occlusion, and angiography confirmed thrombotic occlusion from the proximal superficial femoral artery to the proximal anterior tibial artery, with distal perfusion dependent on tibioperoneal collateral arteries. Catheter-directed thrombolysis (alteplase 0.5 mg/h for 24 hours with low-dose heparin) followed by balloon angioplasty (3.5 × 120 mm and 4.0 × 150 mm) of the popliteal and proximal anterior tibial segments successfully restored distal flow. Through multidisciplinary collaboration, progressive wound healing was achieved, and major amputation was avoided.

Conclusion: This case highlights that vascular awareness in non-healing diabetic foot ulcers, together with multidisciplinary collaboration is the key to achieving limb salvage.

Downloads

Download data is not yet available.

References

Mazzolai L, Teixido-Tura G, Lanzi S, Boc V, Bossone E, Brodmann M, et al. 2024 ESC Guidelines for the management of peripheral arterial and aortic diseases : Developed by the task force on the management of peripheral arterial and aortic diseases of the European Society of Cardiology (ESC Endorsed by the European Association fo. Eur Heart J. 2024;45(36):3538–700. doi:10.1093/eurheartj/ehae179 PubMed PMID: 39210722.

Conte MS, Bradbury AW, Kolh P, White J V., Dick F, Fitridge R, et al. Global Vascular Guidelines on the Management of Chronic Limb-Threatening Ischemia. European Journal of Vascular and Endovascular Surgery. 2019;58(1):S1-S109.e33. doi:10.1016/j.ejvs.2019.05.006 PubMed PMID: 31182334.

Gornik HL, Aronow HD, Goodney PP, Arya S, Brewster LP, Byrd L, et al. 2024 ACC/AHA/AACVPR/APMA/ABC/SCAI/SVM/SVN/SVS/SIR/VESS Guideline for the Management of Lower Extremity Peripheral Artery Disease: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2024;83(24):2497–604. doi:10.1016/j.jacc.2024.02.013 PubMed PMID: 38743805.

Farber A, Menard MT, Conte MS, Kaufman JA, Powell RJ, Choudhry NK, et al. Surgery or Endovascular Therapy for Chronic Limb-Threatening Ischemia. New England Journal of Medicine. 2022;387(25):2305–16. doi:10.1056/nejmoa2207899 PubMed PMID: 36342173.

Schaper NC. Diabetes Metabolism Res - 2023 - Schaper - Practical guidelines on the prevention and management of diabetes‐related foot.pdf. 2023.

Fu M, Zhang H. Global burden of peripheral arterial disease and its risk factors, 1990–2021. BMC Cardiovasc Disord. 2025 Dec 1;25(1). doi:10.1186/s12872-025-05055-2

Okunlola AO, Ajao TO, Karim A, Sabi M, Kolawole O, Ugwoke K, et al. A Review of Peripheral Artery Disease in Diabetic Patients in Sub-Saharan Africa. Cureus. 2024 Sep 20. doi:10.7759/cureus.69808

Meza-Torres B, Carinci F, Heiss C, Joy M, de Lusignan S. Health service organisation impact on lower extremity amputations in people with type 2 diabetes with foot ulcers: systematic review and meta-analysis. Acta Diabetol. 2021 Jun 1;58(6):735–47. doi:10.1007/s00592-020-01662-x PubMed PMID: 33547497.

Gong M, He X, Zhao B, Kong J, Gu J, Chen G. Endovascular revascularization strategies using catheter-based thrombectomy versus conventional catheter-directed thrombolysis for acute limb ischemia. Thromb J. 2021 Dec 1;19(1). doi:10.1186/s12959-021-00349-9

Sunner SS, Welsh RC, Bainey KR. Medical Management of Peripheral Arterial Disease: Deciphering the Intricacies of Therapeutic Options. CJC Open. Elsevier Inc.; 2021. p. 936–49. doi:10.1016/j.cjco.2021.03.005

Meloni M, Giurato L, Monge L, Miranda C, Scatena A, Ragghianti B, et al. Effect of a multidisciplinary team approach in patients with diabetic foot ulcers on major adverse limb events (MALEs): systematic review and meta-analysis for the development of the Italian guidelines for the treatment of diabetic foot syndrome. Acta Diabetologica. Springer-Verlag Italia s.r.l.; 2024. p. 543–53. doi:10.1007/s00592-024-02246-9 PubMed PMID: 38461443.

Beschorner U, Boehme T, Noory E, Bollenbacher R, Salm J, Mashayekhi K, et al. Catheter-Directed Thrombolysis in the Management of Thrombotic Peripheral Artery Occlusions—Acute and Mid-Term Clinical Outcomes. J Clin Med. 2024 Oct 1;13(19). doi:10.3390/jcm13195732

Müller AM, Räpple V, Bradaric C, Koppara T, Kehl V, Fusaro M, et al. Outcomes of endovascular treatment for infrapopliteal peripheral artery disease based on the updated TASC II classification. Vascular Medicine (United Kingdom). 2021 Feb 1;26(1):18–25. doi:10.1177/1358863X20967091 PubMed PMID: 33256573.

Li W, Zaid Al-Kaylani A, Zeebregts CJ, El Moumni M, de Vries JPPM, van der Doef HPJ, et al. Effectiveness and safety of catheter-directed thrombolysis in conjunction with percutaneous mechanical thrombectomy for acute iliofemoral deep vein thrombosis: A meta-analysis. Journal of Vascular Surgery: Venous and Lymphatic Disorders. Elsevier Inc.; 2023. p. 843-853.e2. doi:10.1016/j.jvsv.2023.01.010 PubMed PMID: 36893883.

Orrapin S, Siribumrungwong B. Successful Revascularization, Angiosome Concept, and Multivessel Revascularization: Effects on Wound Healing: An Asian Perspective. International Journal of Lower Extremity Wounds. 2024;23(1):12–8. doi:10.1177/15347346231212330 PubMed PMID: 37933151.

Choi T, Osuagwu UL, Tran C, Bulsari K, Simmons D. Impact of multidisciplinary care of diabetic foot infections for inpatients at Campbelltown Hospital. BMC Health Serv Res. 2023 Dec 1;23(1). doi:10.1186/s12913-023-10119-0 PubMed PMID: 37858102.

Bradbury AW, Moakes CA, Popplewell M, Meecham L, Bate GR, Kelly L, et al. A vein bypass first versus a best endovascular treatment first revascularisation strategy for patients with chronic limb threatening ischaemia who required an infra-popliteal, with or without an additional more proximal infra-inguinal revascularisation pr. The Lancet. 2023;401(10390):1798–809. doi:10.1016/S0140-6736(23)00462-2 PubMed PMID: 37116524.

Bonaca MP, Bauersachs RM, Anand SS, Debus ES, Nehler MR, Patel MR, et al. Rivaroxaban in Peripheral Artery Disease after Revascularization. New England Journal of Medicine. 2020 May 21;382(21):1994–2004. doi:10.1056/nejmoa2000052 PubMed PMID: 32222135.

Joglar JA, Chung MK, Armbruster AL, Benjamin EJ, Chyou JY, Cronin EM, et al. 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines. J Am Coll Cardiol. 2024;83(1):109–279. doi:10.1016/j.jacc.2023.08.017

Hallak AO, Hallak FZ. Exercise therapy in the management of peripheral artery disease. Prog Cardiovasc Dis. 2023;75:24–33. doi:10.1016/j.pcad.2023.09.003

Bus SA, Armstrong DG, Gooday C, et al. Guidelines on offloading foot ulcers in persons with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev. 2023;39 Suppl 1:e3610. doi:10.1002/dmrr.3610

Elsayed NA, Aleppo G, Aroda VR, Bannuru RR, Brown FM, Bruemmer D, et al. 16. Diabetes Care in the Hospital: Standards of Care in Diabetes—2023. Diabetes Care. 2023;46(January):S267–78. doi:10.2337/dc23-S016 PubMed PMID: 36507644.

Bus SA, Armstrong DG, Crews RT, Gooday C, Jarl G, Kirketerp-Moller K, et al. Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev. 2024;40(3):34–46. doi:10.1002/dmrr.3644 PubMed PMID: 37226568.

Senneville É, Albalawi Z, van Asten SA, Abbas ZG, Allison G, Aragón-Sánchez J, et al. IWGDF/IDSA guidelines on the diagnosis and treatment of diabetes-related foot infections (IWGDF/IDSA 2023). Diabetes Metab Res Rev. 2024;40(3). doi:10.1002/dmrr.3687 PubMed PMID: 37779323.

Lavery LA, Suludere MA, Attinger CE, Malone M, Kang GE, Crisologo PA, et al. WHS (Wound Healing Society) guidelines update: Diabetic foot ulcer treatment guidelines. Wound Repair and Regeneration. 2024;32(1):34–46. doi:10.1111/wrr.13133 PubMed PMID: 38032324.

Downloads

Published

2026-10-29

How to Cite

Rakhmadhani, I. ., Kurnianingsih, N., Kurniawan, D. A., Mayangsari, V., Bramantya, R. R., & Siswanto, Y. (2026). Vascular Awareness as the Key to Limb Salvage in Diabetes Mellitus. Jurnal Klinik Dan Riset Kesehatan, 6(1), 71-79. https://doi.org/10.11594/jk-risk.06.1.9