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Seborrheic keratosis is the most common benign epidermal tumor and is often found in the elderly, which is about 20% of the total population. The exact cause of this disorder is still not clearly known. Sun exposure is said to be one of the causes of seborrheic keratosis. Lesions can be flat, circumscript and dull-looking brown spots, with a smooth, velvety surface, can also take the form of hyperpimented papules or plaques, round or oval, circumscript, such as coated wax (waxy) with a verrucosa surface, or a picture of sticking "stuck on" to the surface of the skin. skin. Seborrheic keratosis can be in the form of multiple, solitary, disseminated lesions in old age, dermatosis papulosa nigra and also in the form of Leser-Trelat signs. The diagnosis of seborrheic keratosis is made through anamnesis, physical examination and by histopathological examination. There are various histopathological features of seborrheic keratosis, this literature review aims to explain the various clinical features of seborrheic keratosis along with their histopathological features and can assist readers in determining the type of seborrheic keratosis when they come across such cases.

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Mayati Suwoko, W. U. C., Yuniaswan, A., & Retnani, D. (2023). Clinical and Histopathological Features of Seborrheic Keratosis . Jurnal Klinik Dan Riset Kesehatan, 2(2), 280-284.


1. Elston DM. Benign tumors and cyst of the epidermis. In : Elston DM, Ferringer T, edi-tors. Dermatopathology. 2nd Edition. Saunders Elsevier; Philadelphia, Pennsyl-vania, USA : 2014. pp. 37-47
2. Roh NK, Hahn HJ, Lee YW, Choe YB, Ahn KJ. Clinical and Histopathological Investiga-tion of Seborrheic Keratosis. Annals of dermatology. 2006; 28: 152-158
3. Brenn T, Elgart G et al. Benign acanthom-as/keratoses. WHO Classification of Skin Tumours. 4th Edition. IARC: Lyon 2018. pp 57-59
4. Hafner C, Toll A, Fernandez-Casado A, Earl J, Marques M, Acquardo F, Mendez-Pertuz M, Urioste M, Malats N, Burns JE, Knowles MA. Cigudosa JC, Hartmann A, et al. Multi-ple oncogenic mutations and clonal rela-tionship in spatially distinct benign human epidermal tumors. Proc Natl Acad Sci USA. 2010; 107; 20780-20785
5. Gefilem G, Suling P, Kapantouw M. Profil Tumor Jinak Kulit di Poliklinik Kulit dan Kelamin RSUP Prof. Dr. R.D. Kandou Ma-nado Periode 2009-2011. Jurnal E-Clinic.2013;1(1):1-10
6. Wiebe D et al. Seborrheic Keratosis: Path-ogenesis and clinical findings. Calgary Guide. 2014.
7. Thomas VD, Snavely NR, Lee KK, Swanson NA. Benign epithelial tumors, hamartomas, and hyperplasia. Wolff K, Goldsmith LA, Katz SI, Gilchrest BA, Paller AS, Leffel DJ, eds. Fitzpatrick’s Dermatology In General Medicine. 9th edition. New York: McGraw-Hill; 2019.
8. Wollf K, Allen RJ. Benign Neoplasms and hyperplasias. Fitzpatrick’s Color Atlas and Synopsis of Clinical Dermatology. 6th edi-tion. New York: McGraw-Hill; 2009.