Main Article Content


Background: Non-steroidal antiinflammatory drugs (NSAID) is a common drug with an antiinflammation and  an analgesic effect which consumed widely among people. On the other hand, NSAID also have some adverse effects including nefrotic syndrome (NS).

Case Presentation: A man, 20 years old, came with general body swelling. The swelling appeared gradually accompanied by shortness of breath as the body swelling was spread. The patient has a history of frequently consuming pain reliver medications which he bought over the counter, 3-4 times/week since 1 year ago. The patient was diagnosed with nephrotic syndrome. We stop the OAINS and administer some medications, such as, intravenous steroid, oral ARBs, and oral anticoagulant therapy. Patients responded well to the therapy given marked by reduced edema and improved kidney function.

Discussion: NS is glomerular syndrome consists of massive proteinuria, hypoalbuminemia, peripheral oedema, and/or hyperlipidemia. The etiology of NS divided into 2 group : primary NS and secondary NS. The primary NS such as minimal change disease glomerulonephritis, membranous nephropathy, focal segmental glomerulonephritis, and IgA nephropathy. In the other hand, secondary SN can be caused by NSAID toxicity, infection, metabolic dysfunction, and autoimmune disease.

Conclusion: In this case report, a male, 20 years old is diagnosed with NS and had medical history of being long term NSAID’s user who responded well after given steroid therapy. In order to find the definite etiology of SN, it need adjunct examination such as renal biopsy. Moreover, medical practitioner should do the holistic and comprehensive anamnesis and physical examination associated with the risk of NS.

Article Details

How to Cite
Mumtaza, H. I., & Rochmah, I. (2023). A Case Report Nephrotic Syndrome on Non-steroidal Antiinflammatory Drug (NSAID) User in Adult: A Case Report. Jurnal Klinik Dan Riset Kesehatan, 2(2), 315-322.


1. Lydia A, Marbun M. Sindrom Nefrotik. In: Buku Ajar Ilmu Penyakit Dalam. 6th ed. Jakarta: In-terna Publishing; 2014. p. 2080–7.
2. Kodner C. Diagnosis and Management of Ne-phrotic Syndrome in Adults. 2016;93(6).
3. Mérida E, Praga M. NSAIDs and Nephrotic Syn-drome. CJASN [Internet]. 2019 Sep 6 [cited 2023 Jan 6];14(9):1280–2. Available from:
4. Drożdżal S, Lechowicz K, Szostak B, Rosik J, Kotfis K, Machoy‐Mokrzyńska A, et al. Kidney damage from nonsteroidal anti‐inflammatory drugs—Myth or truth? Review of selected liter-ature. Pharmacol Res Perspect [Internet]. 2021 Aug [cited 2023 Jan 6];9(4). Available from:
5. Ogawa-Furuya N, Yano S, Takeno A, Yamane Y, Tanaka S, Sugimoto T. A Case of NSAIDs-Induced Nephrotic Syndrome Associated with Renal Tubular Injury in the Course of Diabetic Nephropathy. 2014;
6. Bakhriansyah M, Souverein PC, van den Hoogen MWF, de Boer A, Klungel OH. Risk of Nephrotic Syndrome for Non-Steroidal Anti-Inflammatory Drug Users. CJASN [Internet]. 2019 Sep 6 [cited 2023 Jan 6];14(9):1355–62. Available from:
7. Nishi S, Ubara Y, Utsunomiya Y, Okada K, Obata Y, Kai H, et al. Evidence-based clinical practice guidelines for nephrotic syndrome 2014. Clin Exp Nephrol [Internet]. 2016 Jun [cited 2023 Jan 6];20(3):342–70. Available from:
8. Wang C shi, Greenbaum LA. Nephrotic Syn-drome. Pediatric Clinics of North America [In-ternet]. 2019 Feb [cited 2023 Jan 6];66(1):73–85. Available from:
9. Prodjosudjadi. Glomerulonefritis. In: Buku Ajar Ilmu Penyakit Dalam. 6th ed. Jakarta: Interna Publishing; 2014.
10. Neupane S, Pudasaini P, Sharma A, Sharma S, Adhikari A, Roka K. Minimal Change Disease in an Adult: A Case Report. J Nepal Med Assoc. 2022 Apr 15;60(248):399–401.
11. Lucas GNC, Leitão ACC, Alencar RL, Xavier RMF, Daher EDF, Silva Junior GB da. Pathophysiologi-cal aspects of nephropathy caused by non-steroidal anti-inflammatory drugs. Braz J Neph-rol [Internet]. 2019 Mar [cited 2023 Jan 6];41(1):124–30. Available from:
12. Vega J, Goecke H, Méndez GP, Guarda FJ. Ne-phrotic Syndrome and Acute Tubular Necrosis Due to Meloxicam Use. Renal Failure [Internet]. 2012 Nov [cited 2023 Jan 26];34(10):1344–7. Available from:
13. Canetta PAA, Radhakrishnan J. The Evidence-Based Approach to Adult-Onset Idiopathic Ne-phrotic Syndrome. Front Pediatr [Internet]. 2015 Sep 25 [cited 2023 Jan 6];3. Available from:
14. Hogan J, Radhakrishnan J. The Treatment of Minimal Change Disease in Adults. Journal of the American Society of Nephrology [Internet]. 2013 May [cited 2023 Jan 27];24(5):702–11. Available from:
15. Koirala A, Jefferson JA. Steroid Minimization in Adults with Minimal Change Disease. Glomeru-lar Dis [Internet]. 2021 Jul 29 [cited 2023 Jan 27];1(4):237–49. Available from: