Main Article Content

Abstract

Metastasis has been literally defined as the spread of cancer from the main body part when the cancer starts to induce other parts of the body. Approximately, one third of patients with advanced renal cell carcinoma (RCC) have presented bone metastases which are often osteolytic causing substantial morbidity, such as: pain pathological fractures, spinal cord compression and hypercalcemia. Additionally, the presence of bone metastases in RCC is also associated with a poor prognosis. This paper reports a case presentation regarding embolization in a case of a 25-year-old female patient with a pathological diagnosis of a pathological fracture at the L1 level dt MBD Process Renal Cell Carcinoma prior to spinal stabilization surgery. Embolization hence plays an important role in treating hypervascular bone metastases, providing effective means of treating hemorrhagic conditions by minimizing the bleeding supply to tumor masses. In sum, embolization could be performed either as a definitive treatment or as an adjunct to subsequent surgical management.

Article Details

How to Cite
Rizqi, P., Setyawan, A., & Achmad. (2022). Preoperative Trans Arterial Embolization in Metastatic Bone Disease from Renal Cell Carcinoma. Jurnal Klinik Dan Riset Kesehatan, 1(3), 187-195. https://doi.org/10.11594/jk-risk.01.3.7

References

1. Chen S-C, Kuo P-L. Bone Metastasis from Renal Cell Carcinoma. Int J Mol Sci. 2016 Jun;17(6).
2. Olerud C, Jónsson HJ, Löfberg AM, Lörelius LE, Sjöström L. Embolization of spinal metastases reduces peroperative blood loss. 21 patients operated on for renal cell carcinoma. Acta Or-thop Scand. 1993 Feb;64(1):9–12.
3. Pazionis TJC, Papanastassiou ID, Maybody M, Healey JH. Embolization of hypervascular bone metastases reduces intraoperative blood loss: a case-control study. Clin Orthop Relat Res. 2014 Oct;472(10):3179–87.
4. Rossi G, Mavrogenis AF, Casadei R, Bianchi G, Romagnoli C, Rimondi E, et al. Embolisation of bone metastases from renal cancer. Radiol Med. 2013 Mar;118(2):291–302.
5. Manke C, Bretschneider T, Lenhart M, Strotzer M, Neumann C, Gmeinwieser J, et al. Spinal me-tastases from renal cell carcinoma: effect of preoperative particle embolization on in-traoperative blood loss. AJNR Am J Neuroradiol. 2001 May;22(5):997–1003.
6. Sun S. Bone Metastases from Renal Cell Carci-noma: Preoperative Embolization. In: Golzarian J, Sun S, Sharafuddin MJ, editors. Vascular Em-bolotherapy: A Comprehensive Approach Vol-ume 2 Oncology, Trauma, Gene Therapy, Vascu-lar Malformations, and Neck [Internet]. Berlin, Heidelberg: Springer Berlin Heidelberg; 2006. p. 189–99. Available from: https://doi.org/10.1007/3-540-33257-X_15
7. Swanson DA, Orovan WL, Johnson DE, Giacco G. Osseous metastases secondary to renal cell car-cinoma. Urology. 1981 Dec;18(6):556–61.
8. Selli C, Hinshaw WM, Woodard BH, Paulson DF. Stratification of risk factors in renal cell carci-noma. Cancer. 1983 Sep;52(5):899–903.
9. Kessler O, Mukamel E, Hadar H, Gillon G, Konechezky M, Servadio C. Effect of improved diagnosis of renal cell carcinoma on the course of the disease. J Surg Oncol. 1994 Nov;57(3):201–4.
10. Maldazys JD, deKernion JB. Prognostic fac-tors in metastatic renal carcinoma. J Urol. 1986 Aug;136(2):376–9.
11. Radeleff B, Eiers M, Lopez-Benitez R, No-eldge G, Hallscheidt P, Grenacher L, et al. Transarterial embolization of primary and sec-ondary tumors of the skeletal system. Eur J Ra-diol. 2006 Apr;58(1):68–75.
12. Hess T, Kramann B, Schmidt E, Rupp S. Use of preoperative vascular embolisation in spinal metastasis resection. Arch Orthop Trauma Surg. 1997;116(5):279–82.
13. Chatziioannou AN, Johnson ME, Pneumati-cos SG, Lawrence DD, Carrasco CH. Preoperative embolization of bone metastases from renal cell carcinoma. Eur Radiol. 2000;10(4):593–6.
14. Roscoe MW, McBroom RJ, St Louis E, Gross-man H, Perrin R. Preoperative embolization in the treatment of osseous metastases from renal cell carcinoma. Clin Orthop Relat Res. 1989 Jan;(238):302–7.