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Moisturizer is the main component of daily basic skin care especially if there is a change in the epidermal barrier and reduced water content in the epidermis layer. When the amount of water drop below 10%, the skin become dry. One of herbal plants that affect skin hydration is Centella asiatica. C. asiatica is known as Pegagan in Indonesia and belongs to the Umbelliferae/Apiaceae family. Extracts from the leaves of C. asiatica have been reported to have potential as antioxidants, antimicrobial agents, collagen synthesis agents, and even act as wound healing properties. The active components of C. asiatica include pentacyclic triterpenes, particularly asiaticoside, madecassoside, asiatic acid and madecassic acid. C. asiatica is used as an active compound in skin care preparations due to its hydrating, antioxidant, anti-inflammatory, anti-cellulite and anti-aging activities. A formulation containing a concentration of C. asiatica extract showed efficacy in increasing skin moisture by increasing the hydration state of the skin surface and reducing the occurrence of transepidermal water loss (TEWL). This literature review aims to add insight about Centella asiatica and its mechanism of action that can be used as a moisturizer for the skin. Centella asiatica can be used as a cosmetic formulation that can treat dry and sensitive skin. More research is needed to identify and determine the chemical compound C. asiatica which is responsible for various therapeutic activities, especially as an effective, safe, easy and inexpensive moisturizer.

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1. Butarbutar MET, Chaerunisaa AY. Peran Pelembab dalam Mengatasi Kondisi Kulit Kering. Maj Farmasetika. 2020;6(1):56-69. doi:10.24198/mfarmasetika.v6i1.28740
2. Damasceno GA de B, Silva RMA da C, Fer-nandes JM, Ostrosky EA, Langassner SMZ, Ferrari M. Use of Opuntia ficus-indica (L.) Mill extracts from Brazilian Caatinga as an al-ternative of natural moisturizer in cosmetic formulations. Brazilian J Pharm Sci. 2016;52(3):459-470.
3. Sabila FC, Muhartono. Efektivitas Pemberian Ekstrak Daun Pegagan ( Centella asiatica ) terhadap Penyembuhan Luka The Effectivity of Giving Gotu Kola Leaf Extract ( Centella asiatica ) to Wound Healing. Lit Rev. 2020;7:23-29.
4. Prakash V, Jaiswal N, Srivastava M. A review on medicinal properties of Centella asiatica. Asian J Pharm Clin Res. 2017;10(10):69-74. doi:10.22159/ajpcr.2017.v10i10.20760
5. Belwal T, Andola HC, Atanassova MS, et al. Gotu Kola (Centella Asiatica). Elsevier Inc.; 2018. doi:10.1016/B978-0-12-812491-8.00038-2
6. Udompataikul M. New innovation of moistur-izers containing non-steroidal anti-inflammatory agents for atopic dermatitis. 2015;4(2):108-113. doi:10.5314/WJD.V4.I2.108
7. K N, E M. Moisturizers: reality and the skin benefits. Dermatol Ther. 2012;25(3):229-233. doi:10.1111/J.1529-8019.2012.01504.X
8. Draelos ZD. The science behind skin care: Moisturizers. J Cosmet Dermatol. 2018;17(2):138-144. doi:10.1111/jocd.12490
9. Wan DC, Wong VW, Longaker MT, Yang GP, Wei F-C. Moisturizing Different Racial Skin Types. J Clin Aesthet Dermatol. 2014;7(6):25. Accessed September 27, 2021. /pmc/articles/PMC4086530/
10. Purnamawati S, Indrastuti N, Danarti R, Saefudin T. The Role of Moisturizers in Ad-dressing Various Kinds of Dermatitis: A Re-view. Clin Med Res. 2017;15(3-4):75. doi:10.3121/CMR.2017.1363
11. Yasurin P, Sriariyanun M, Phusantisampan T. Review: The Bioavailability Activity of Cen-tella asiatica. KMUTNB Int J Appl Sci Technol. 2015;9(1):1-9. doi:10.14416/j.ijast.2015.11.001
12. Sholikhah, L.L., 2014. Pengaruh Fe2+ pada media MS dengan penambahan 2, 4-D yang dikombinasikan dengan air kelapa terhadap perkembangan dan kandungan metabolit sekunder asiatikosida dan madekasosida ka-lus pegagan (Centella asiatica L. Urban) (Doctoral dis UINMMI. PENGARUH Fe 2+ PADA MEDIA MS.
13. Azis HA, Taher M, Ahmed AS, et al. In vitro and In vivo wound healing studies of meth-anolic fraction of Centella asiatica extract. South African J Bot. 2017;108:163-174. doi:10.1016/j.sajb.2016.10.022
14. Chandrika UG, Prasad Kumara PAAS. Gotu Kola (Centella Asiatica): Nutritional Proper-ties and Plausible Health Benefits. Vol 76. 1st ed. Elsevier Inc.; 2015. doi:10.1016/bs.afnr.2015.08.001
15. Monton C, Settharaksa S, Luprasong C, Song-sak T. An optimization approach of dynamic maceration of Centella asiatica to obtain the highest content of four centelloids by re-sponse surface methodology. Rev Bras Far-macogn. 2019;29(2):254-261. doi:10.1016/j.bjp.2019.01.001
16. Ratz-Łyko A, Arct J, Pytkowska K. Moisturiz-ing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract. Indian J Pharm Sci. 2016;78(1):27. Accessed September 28, 2021. /pmc/articles/PMC4852572/
17. Milani M, Sparavigna A. The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: An intra-subject, randomized, assessor-blinded study. Clin Cosmet Investig Derma-tol. 2017;10:311-315. doi:10.2147/CCID.S144180
18. Wijayadi LY, Darmawan H. Asiaticoside in-creases aquaporin-3 protein expression in the cytoplasm of normal human epidermal keratinocytes. Universa Med. 2017;36(1):25. doi:10.18051/univmed.2017.v36.25-33
19. Yulianti L, Bramono K, Mardliyati E, et al. Ek-spresi protein aquaporin3 pada fibroblas dan keratinosit kulit manusia yang diinduksi oleh nanopartikel kitosan. Maj Ilm Resmi Perhimpun Dr Spes Kulit dan Kelamin In-dones. 2015;42(1):7-17.
20. Yulianti L, Yulianti L, Bramono K, Mardliyati E, Freisleben H-J. Effects of Centella asiatica Ethanolic Extract Encapsulated in Chitosan Nanoparticles on Proliferation Activity of Skin Fibroblasts and Keratinocytes, Type I and III Collagen Synthesis and Aquaporin 3 Expression In vitro. J Pharm Biomed Sci. 2016;6(5). Accessed September 28, 2021.
21. Venesia NF, Fachrial E, Lister IN. Effective-ness Test of Centella Asiatica Extract on Im-provement of Collagen and Hydration in Fe-male White Rat (Rattus Norwegicus Wistar). Technol Sci Am Sci Res J Eng. 2020;65(1):98-107.
22. Saraf S, Chhabra SK, Kaur CD, Saraf S. De-velopment of photochemoprotective herbs containing. J Cosmet Sci. 2012;63(April):119-131.
23. Nema NK, Maity N, Sarkar BK, Mukherjee PK. Matrix metalloproteinase, hyaluronidase and elastase inhibitory potential of standard-ized extract of Centella asiatica. Pharm Biol. 2013;51(9):1182-1187. doi:10.3109/13880209.2013.782505
24. Bylka W, Znajdek-Awizeń P, Studzińska-Sroka E, Dańczak-Pazdrowska A, Brzezińska M. Centella asiatica in dermatology: An over-view. Phyther Res. 2014;28(8):1117-1124. doi:10.1002/ptr.5110
25. Hasanah 2016. Perbandingan efektivitas dan keamanan krim pelembap yang mengandung Centella asiatica ekstrak etanol dalam nanopartikel kitosan dengan Centella asiatica ekstrak etanol dan dengan krim pelembap dasar terhadap kulit kering pada populasi geriatri. Perbandingan efektivitas dan keamanan krim pelembap yang mengandung. Published online 2016.
26. Shen X, Guo M, Yu H, Liu D, Lu Z, Lu Y. Pro-pionibacterium acnes related anti-inflammation and skin hydration activities of madecassoside, a pentacyclic triterpene sap-onin from Centella asiatica. Biosci Biotechnol Biochem. 2019;83(3):561-568. doi:10.1080/09168451.2018.1547627
27. Muhammed Majeed, Vaidyanathan P, Mundkur LA, Majeed S, Sable P, Vuppala KK. Efficacy of centella asiatica extract in the management of cracked feet: in vitro and clinical evidence. World J Pharm Pharm Sci. 2016;5(12):983-992. doi:10.20959/wjpps201612-8213
28. Bylka W, Znajdek-Awizeń P, Studzińska-Sroka E, Brzezińska M. Centella asiatica in cosmetology. Postep Dermatologii i Alergol. 2013;30(1):46-49. doi:10.5114/pdia.2013.33378
29. Edwards SE, Rocha I, Williamson EM, Hein-rich M. Edwards SE, da Costa Rocha I, Wil-liamson EM, Heinrich M. Phytopharmacy: An evidence-based guide to herbal medicinal products. John Wiley & Sons; 2015 Apr 27.