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Oct 25, 2022
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Abstract
Dermatitis atopi merupakan penyakit yang prevalensinya semakin meningkat. Pengetahuan terkini menyebutkan bahwa faktor penyebab dermatitis atopi berhubungan dengan banyak faktor1. Mekanisme yang berhubungan erat dengan dermatitis atopi adalah mekanisme imunologi. Salah satu strategi terapi utama dermatitis atopi adalah untuk mengontrol sistem imun tubuh. Modalitas terapi terbaru yang masih diteliti hingga kini adalah terapi Mesenchymal Stem Cells (MSCs) atau sel punca mesenkimal2. Beberapa penelitian terbaru menunjukkan efektivitas MSCs dalam mengontrol sistem imun tubuh sehingga dapat menghambat progresitivas dermatitis atopi.
Article Details
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
Umami, H. R. (2022). A Review A Review: Effectivity and Immunology of HuCB-MSCs Therapy in Atopic Dermatitis. Jurnal Klinik Dan Riset Kesehatan, 2(1), 235-240. https://doi.org/10.11594/jk-risk.02.1.5
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19. Lee, Byung-Chul, Kim, Jae-Jun., dkk. Disease-specific primed human adult stem cells effective-ly ameliorate experimental atopic dermatitis in mice. Theranostics. 2019 May 26;9 (12):3608-3621. Doi : 10.7150/thno.32945
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2. Bylund, Simon, Kobyletzki, Laura B., dkk. Preva-lence and Incidence of Atopic Dermatitis : A Sys-tematic Review. Acta Derm Venereol. 2020. Doi : 10.2340/00015555-3510
3. Ezzedine, Khaled., Shourick, Jason., dkk. Impact of Atopic Dermatitis in Adolscents amd their Par-ents : A French Study. Acta Derm Venereol. 2020. doi: 10.2340/00015555-3653.
4. Torres, Tiago., Ferreira, Eduarda O., dkk. Up-date on Atopic Dermatitis. Acta Med Port. 2019. Doi : 10.20344/amp.11963
5. Fang, Zhifeng., Li, Lingzhi., dkk. Gut Microbiota, Probiotics and Their Interactions in Prevention and Treatment of Atopic Dermatitis : A Review. Front Immunol. 2021. Doi : 10.3389/fimmu.2021.720393
6. Kim, Eun Young,. Kim, Hyuk Soon., dkk. Mesen-chymal stem/stromal cell teraphy in atopic der-matitis and chronic urticaria: immunological and clinical viewpoints. Stem Cell Res Ther. 2021. Doi : 10.1186/s13287-021-02583-4
7. Li, He., Tian, Yunzhe,. Mesenchymal Stem Cells in Allergic Disease : Current Status. Allergology International. 2020. Doi : https://doi.org/10.1016/j.alit.2019.08.001
8. Lee, Seoung Hoon. The advantages and limita-tions of mesenchymal stem cells in clinical appli-cation for treating human diseases. Osteoporos Sarcopenia. 2018 Dec; 4(4):150. Doi : 10.1016/j.afos.2018.11.083
9. Sroka-Tomaszewska, Jowita., Trzeciak, Magda-lena. Molecular Mechanisms of Atopic Dermatitis Pathogenesis. Int J Mol Sci. 2021. Doi : 10.3390/ijms22084130
10. Banchereau J, Briere F, Caux C, Davoust J, Leb-ecque S, Liu YJ, dkk. Immunobiology of dendritic cells. Annu Rev Immunol. 2000. doi:10.1146/annurev.immunol.18.1.767
11. Kusumawati, Dewi., Prakoeswa, Cita Rosita Sig-it., Rahmadewi. Profil Kadar Interleukin-31 Se-rum pada Pasien Dermatitis Atopik. Berkala Ilmu Kesehatan Kulit dan Kelamin. Agustus 2017. Vol 29. No 2.
12. Chiricozzi, Andrea., Maurelli, Martina., dkk. Targeting IL-4 for the Treatment of Atopic Der-matitis. Immunotargets Ther. 2020; 9: 151-156. Doi : 10.2147/ITT.S26370
13. Bieber, Thomas. Interleukin-13: Targeting an un-derestimated cytokine in atopic dermatitis. Aller-gy - European Journal of Allergy and Clinical Immunology. 2019. Doi : https://doi.org/10.1111/all.13954
14. Corcione, Anna., Benvenuto, Federica., dkk. Human Mesenchymal Stem Cells Modulate B-Cell Function. Blood (2006) 107 (1) : 367-372. Doi : https://doi.org/10.1182/blood-2005-07-2657
15. Spaggiari, Grazia Maria., Capobianco, Andrea., dkk. Mesenchymal stem cell-natural killer cell in-teractions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood. 2006. Doi : https://doi.org/10.1182/blood-2006-07-2775
16. Spaggiari, Grazia Maria., Abdelrazik, Heba., dkk. MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood. 2009. Doi : https://doi.org/10.1182/blood-2009-02-203943
17. Kim, Ju-Yeon., Jeon, Hong Bae., dkk. Application of human umbilical cord-blood derived mesen-chymal stem cells in disease models. World J Stem Cells. 2010 Apr 26; 2(2): 34-38. Doi : 10.4252/wjsc.v2.i2.34
18. Kim, Hyung-Sik. Yun, Jun-Won., dkk. Human Umbilical Cord Blood Mesenchymal Stem Cell-Derived PGE2 and TGF-β1 Alleviate Atopic Der-matitis by Reducing Mast Cell Degranulation. Stem Cells. 2015. Vol 33. Doi : https://doi.org/10.1002/stem.1913
19. Lee, Byung-Chul, Kim, Jae-Jun., dkk. Disease-specific primed human adult stem cells effective-ly ameliorate experimental atopic dermatitis in mice. Theranostics. 2019 May 26;9 (12):3608-3621. Doi : 10.7150/thno.32945
20. Kim, Hyung-Sik., Lee, Ji Hyun., dkk. Clinical Trial of Human Umbilical Cord Blood-Derived Stem Cells for the Treatment of Moderate-to-Severe Atopic Dermatitis: Phase I/IIa Studies. Stem Cells. 2017. Vol 35. Doi : https://doi.org/10.1002/stem.2401