A Review A Review: Effectivity and Immunology of HuCB-MSCs Therapy in Atopic Dermatitis
DOI:
https://doi.org/10.11594/jk-risk.02.1.5Keywords:
Dermatitis atopiAbstract
Dermatitis atopi merupakan penyakit yang prevalensinya semakin meningkat. Pengetahuan terkini menyebutkan bahwa faktor penyebab dermatitis atopi berhubungan dengan banyak faktor1. Mekanisme yang berhubungan erat dengan dermatitis atopi adalah mekanisme imunologi. Salah satu strategi terapi utama dermatitis atopi adalah untuk mengontrol sistem imun tubuh. Modalitas terapi terbaru yang masih diteliti hingga kini adalah terapi Mesenchymal Stem Cells (MSCs) atau sel punca mesenkimal2. Beberapa penelitian terbaru menunjukkan efektivitas MSCs dalam mengontrol sistem imun tubuh sehingga dapat menghambat progresitivas dermatitis atopi.
Downloads
References
Boediardja, Siti Aisah. 1987. Buku Ilmu Penya-kit Kulit. Edisi ketujuh, Cetakan kedua 2016. Hal 167-183. Badan Penerbit FKUI : Jakarta
Bylund, Simon, Kobyletzki, Laura B., dkk. Preva-lence and Incidence of Atopic Dermatitis : A Sys-tematic Review. Acta Derm Venereol. 2020. Doi : 10.2340/00015555-3510
Ezzedine, Khaled., Shourick, Jason., dkk. Impact of Atopic Dermatitis in Adolscents amd their Par-ents : A French Study. Acta Derm Venereol. 2020. doi: 10.2340/00015555-3653.
Torres, Tiago., Ferreira, Eduarda O., dkk. Up-date on Atopic Dermatitis. Acta Med Port. 2019. Doi : 10.20344/amp.11963
Fang, Zhifeng., Li, Lingzhi., dkk. Gut Microbiota, Probiotics and Their Interactions in Prevention and Treatment of Atopic Dermatitis : A Review. Front Immunol. 2021. Doi : 10.3389/fimmu.2021.720393
Kim, Eun Young,. Kim, Hyuk Soon., dkk. Mesen-chymal stem/stromal cell teraphy in atopic der-matitis and chronic urticaria: immunological and clinical viewpoints. Stem Cell Res Ther. 2021. Doi : 10.1186/s13287-021-02583-4
Li, He., Tian, Yunzhe,. Mesenchymal Stem Cells in Allergic Disease : Current Status. Allergology International. 2020. Doi : https://doi.org/10.1016/j.alit.2019.08.001
Lee, Seoung Hoon. The advantages and limita-tions of mesenchymal stem cells in clinical appli-cation for treating human diseases. Osteoporos Sarcopenia. 2018 Dec; 4(4):150. Doi : 10.1016/j.afos.2018.11.083
Sroka-Tomaszewska, Jowita., Trzeciak, Magda-lena. Molecular Mechanisms of Atopic Dermatitis Pathogenesis. Int J Mol Sci. 2021. Doi : 10.3390/ijms22084130
Banchereau J, Briere F, Caux C, Davoust J, Leb-ecque S, Liu YJ, dkk. Immunobiology of dendritic cells. Annu Rev Immunol. 2000. doi:10.1146/annurev.immunol.18.1.767
Kusumawati, Dewi., Prakoeswa, Cita Rosita Sig-it., Rahmadewi. Profil Kadar Interleukin-31 Se-rum pada Pasien Dermatitis Atopik. Berkala Ilmu Kesehatan Kulit dan Kelamin. Agustus 2017. Vol 29. No 2.
Chiricozzi, Andrea., Maurelli, Martina., dkk. Targeting IL-4 for the Treatment of Atopic Der-matitis. Immunotargets Ther. 2020; 9: 151-156. Doi : 10.2147/ITT.S26370
Bieber, Thomas. Interleukin-13: Targeting an un-derestimated cytokine in atopic dermatitis. Aller-gy - European Journal of Allergy and Clinical Immunology. 2019. Doi : https://doi.org/10.1111/all.13954
Corcione, Anna., Benvenuto, Federica., dkk. Human Mesenchymal Stem Cells Modulate B-Cell Function. Blood (2006) 107 (1) : 367-372. Doi : https://doi.org/10.1182/blood-2005-07-2657
Spaggiari, Grazia Maria., Capobianco, Andrea., dkk. Mesenchymal stem cell-natural killer cell in-teractions: evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NK-cell proliferation. Blood. 2006. Doi : https://doi.org/10.1182/blood-2006-07-2775
Spaggiari, Grazia Maria., Abdelrazik, Heba., dkk. MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2. Blood. 2009. Doi : https://doi.org/10.1182/blood-2009-02-203943
Kim, Ju-Yeon., Jeon, Hong Bae., dkk. Application of human umbilical cord-blood derived mesen-chymal stem cells in disease models. World J Stem Cells. 2010 Apr 26; 2(2): 34-38. Doi : 10.4252/wjsc.v2.i2.34
Kim, Hyung-Sik. Yun, Jun-Won., dkk. Human Umbilical Cord Blood Mesenchymal Stem Cell-Derived PGE2 and TGF-β1 Alleviate Atopic Der-matitis by Reducing Mast Cell Degranulation. Stem Cells. 2015. Vol 33. Doi : https://doi.org/10.1002/stem.1913
Lee, Byung-Chul, Kim, Jae-Jun., dkk. Disease-specific primed human adult stem cells effective-ly ameliorate experimental atopic dermatitis in mice. Theranostics. 2019 May 26;9 (12):3608-3621. Doi : 10.7150/thno.32945
Kim, Hyung-Sik., Lee, Ji Hyun., dkk. Clinical Trial of Human Umbilical Cord Blood-Derived Stem Cells for the Treatment of Moderate-to-Severe Atopic Dermatitis: Phase I/IIa Studies. Stem Cells. 2017. Vol 35. Doi : https://doi.org/10.1002/stem.2401
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal the right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors can enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) before and during the submission process, as it can lead to productive exchanges and earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
