Main Article Content

Abstract

Disfungsi seksual merupakan kasus yang cukup banyak terjadi, baik sebagai komplikasi dari penyakit kronik atau salah satu gejala dari depresi, tetapi jarang didiagnosis sehingga masalah tersebut tidak teratasi dan bisa menyebabkan penurunan kualitas hidup pasien. Kesulitan dalam diagnosis maupun terapi ini bisa terjadi karena disfungsi seksual merupakan keluhan yang jarang diungkap oleh pasien terutama penderita penyakit kronik, selain itu disfungsi seksual juga mempunyai hubungan dua arah dengan kondisi depresi. Skrining faktor hormonal, vaskular, neurogenik, dan farmakologi perlu dikerjakan untuk penilaian klinis pasien dengan disfungsi seksual, sehingga bisa diberikan tindak lanjut yang adekuat.

Article Details

References

1. Santana LM, Perin L, Lunelli R, Inácio JFS, Rodrigues CG, Eibel B, et al. Sexual Dysfunction in Women with Hypertension: a Systematic Review and Meta-analysis. Curr Hypertens Rep. 2019 Apr;21(3):25.
2. Münzel T, Gori T. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol. 2009 Oct;54(16):1491–9.
3. Bacon CG, Mittleman MA, Kawachi I, Giovannucci E, Glasser DB, Rimm EB. Sexual function in men older than 50 years of age: results from the health professionals follow-up study. Ann Intern Med. 2003 Aug;139(3):161–8.
4. Chokka PR, Hankey JR. Assessment and management of sexual dysfunction in the context of depression. Ther Adv Psychopharmacol. 2018 Jan;8(1):13–23.
5. Manolis A, Doumas M. Sexual dysfunction: the “prima ballerina” of hypertension-related quality-of-life complications. J Hypertens. 2008 Nov;26(11):2074–84.
6. Vecchio M, Palmer SC, Tonelli M, Johnson DW, Strippoli GFM. Depression and sexual dysfunction in chronic kidney disease: a narrative review of the evidence in areas of significant unmet need. Vol. 27, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. England; 2012. p. 3420–8.
7. Costa MR, Ponciano VC, Costa TR, de Oliveira AM, Gomes CP, de Oliveira EC. Prevalence and factors associated with erectile dysfunction in patients with chronic kidney disease on conservative treatment. Int J Impot Res. 2017 Nov;29(6):219–24.
8. Rosas SE, Joffe M, Franklin E, Strom BL, Kotzker W, Brensinger C, et al. Prevalence and determinants of erectile dysfunction in hemodialysis patients. Kidney Int [Internet]. 2001;59(6):2259–66. Available from: https://www.sciencedirect.com/science/article/pii/S008525381547721X
9. Mendes Ribeiro AC, Brunini TM, Ellory JC, Mann GE. Abnormalities in L-arginine transport and nitric oxide biosynthesis in chronic renal and heart failure. Cardiovasc Res. 2001 Mar;49(4):697–712.
10. Argyriou AA, Cavaletti G, Antonacopoulou A, Genazzani AA, Briani C, Bruna J, et al. Voltage-gated sodium channel polymorphisms play a pivotal role in the development of oxaliplatin-induced peripheral neurotoxicity: results from a prospective multicenter study. Cancer. 2013 Oct;119(19):3570–7.
11. Jankowska EA, Filippatos G, Ponikowska B, Borodulin-Nadzieja L, Anker SD, Banasiak W, et al. Reduction in circulating testosterone relates to exercise capacity in men with chronic heart failure. J Card Fail. 2009 Jun;15(5):442–50.
12. Clayton AH, El Haddad S, Iluonakhamhe J-P, Ponce Martinez C, Schuck AE. Sexual dysfunction associated with major depressive disorder and antidepressant treatment. Expert Opin Drug Saf. 2014 Oct;13(10):1361–74.
13. Atlantis E, Sullivan T. Bidirectional association between depression and sexual dysfunction: a systematic review and meta-analysis. J Sex Med. 2012 Jun;9(6):1497–507.
14. Simopoulos EF, Trinidad AC. Male erectile dysfunction: integrating psychopharmacology and psychotherapy. Gen Hosp Psychiatry. 2013;35(1):33–8.
15. Diaz VAJ, Close JD. Male sexual dysfunction. Prim Care. 2010 Sep;37(3):473–89, vii–viii.
16. Doumas M, Boutari C, Viigimaa M. Arterial Hypertension and erectile dysfunction: an under- recognized duo. Eur Soc Cardiol [Internet]. 2016;14(Feb):4–23. Available from: http://www.escardio.org/Journals/E-Journal-of-Cardiology-Practice/Volume-14/arterial-hypertension-and-erectile-dysfunction-an-under-recognized-duo
17. Düsing R. Sexual dysfunction in male patients with hypertension: influence of antihypertensive drugs. Drugs. 2005;65(6):773–86.
18. Fogari R, Preti P, Derosa G, Marasi G, Zoppi A, Rinaldi A, et al. Effect of antihypertensive treatment with valsartan or atenolol on sexual activity and plasma testosterone in hypertensive men. Eur J Clin Pharmacol. 2002 Jun;58(3):177–80.
19. Angulo J, Wright HM, Cuevas P, González-Corrochano R, Fernández A, Cuevas B, et al. Nebivolol dilates human penile arteries and reverses erectile dysfunction in diabetic rats through enhancement of nitric oxide signaling. J Sex Med. 2010 Aug;7(8):2681–97.
20. Doumas M, Douma S. The effect of antihypertensive drugs on erectile function: a proposed management algorithm. J Clin Hypertens (Greenwich). 2006 May;8(5):359–64.