Cardiovascular Risks in Radiation Therapy: A Clinical Overview of Radiation-Induced Heart Disease
DOI:
https://doi.org/10.11594/jk-risk.04.2.5Keywords:
radiation therapy, echocardiography, cardiotoxicity, cardio-oncologyAbstract
Radiotherapy, which has become a pivotal part of cancer treatment over the past 50 years, has indeed proven to increase patient cure rates. However, despite its success, radiotherapy also carries inevitable side effects on the cardiovascular system, specifically radiation-induced heart disease (RIHD). RIHD encompasses a variety of heart diseases, including pericardial disease, coronary artery disease, valvular heart disease, conduction system abnormalities, cardiomyopathy, and vascular disease of medium or large vessels. These side effects can result from the direct impact of radiation on the function and structure of the heart or by accelerating the progression of pre-existing cardiovascular diseases, especially in patients with prior cardiovascular risk factors. Scientists have now developed non-invasive methods to detect RIHD. Additionally, various efforts are being made to prevent and minimize RIHD. This review delves deeper into the pathogenesis, clinical manifestations, diagnosis, management, and prevention of RIHD.
Downloads
References
Juan A. Quintero-Martinez , S.N.C.-M.a.H.R.V., Ra¬diation-Induced Heart Disease. 2022.
R.M. Muratov, S.I.B., M.N. Sorkomov, Current view on radiation-induced heart disease and methods of its diagnosis. 2022. DOI: https://doi.org/10.15825/1995-1191-2022-4-39-45
Rosenblatt, E., RADIOTHERAPY IN CANCER CARE: FACING THE GLOBAL CHALLENGE. 2020.
Eve Belzile-Dugas , M.M.J.E., MD, MPH, Radia-tion-Induced Cardiovascular Disease: Review of an Underrecognized Pathology. 2021. DOI: https://doi.org/10.1161/JAHA.121.021686
Siti Utami Dewi, A.A., Impact of radiation ther-apy on the heart. 2022.
Konstantinos C. Siaravas , C.S.K.a.C.S., Radiation Treatment Mechanisms of Cardiotoxicity: A Systematic Review. 2023. DOI: https://doi.org/10.3390/ijms24076272
Wang H, Wei J, Zheng Q, Meng L, Xin Y, Yin X, et al. 2019. Radiation-induced heart disease: a re¬view of classification, mechanism and preven¬tion. Int J Biol Sci, 15:2128-2138. DOI: https://doi.org/10.7150/ijbs.35460
Martinez C, Cicenia M, Sprynger M, Postolache A, Ilardi F, Dulgheru R, Radermecker M, Espos¬ito G, Marechal P, Marechal V, et al. Myocardial function in patients with radiation-associated aortic stenosis undergoing transcatheter aortic valve replacement: a layer-specific strain analysis study. JACC Cardiovasc Imaging. 2020;13:1450–1452. doi: 10.1016/j.jcmg.2020.01.01 DOI: https://doi.org/10.1016/j.jcmg.2020.01.018
Chang AS, Smedira NG, Chang CL, Benavides MM, Myhre U, Feng J, Blackstone EH, Lytle BW. Cardiac surgery after mediastinal radiation: ex¬tent of exposure influences outcome. J Thorac Cardiovasc Surg. 2007;133:404–413. doi: 10.1016/j.jtcvs.2006.09.041 DOI: https://doi.org/10.1016/j.jtcvs.2006.09.041
Weintraub NL, Jones WK, Manka D. 2010. Under¬standing radiation-induced vascular dis¬ease. J Am Coll Cardiol, 55:1237-1239. DOI: https://doi.org/10.1016/j.jacc.2009.11.053
Lee MS, Finch W, Mahmud E. 2013. Cardiovas-cular complications of radiotherapy. Am J Car-diol, 112:1688-1696 DOI: https://doi.org/10.1016/j.amjcard.2013.07.031
Yusuf SW, Sami S, Daher IN. 2011. Radiation-in¬duced heart disease: a clinical update. Car¬diol Res Pract, 317659. DOI: https://doi.org/10.4061/2011/317659
Hering D, Faber L, Horstkotte D. Echocardio-graphic features of radiation-associated val-vular disease. Am J Cardiol. 2003;92:226–230. doi: 10.1016/S0002 -9149(03)00546 -0 DOI: https://doi.org/10.1016/S0002-9149(03)00546-0
Donnellan E, Alashi A, Johnston DR, Gillinov AM, Pettersson GB, Svensson LG, Griffin BP, Desai MY. Outcomes of patients with mediasti¬nal radiation-associated mitral valve disease undergoing cardiac surgery. Circulation. 2019;140:1288–1290. doi: 10.1161/CIRCU LATIO NAHA.119.040546 DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.040546
Taunk NK, Haffty BG, Kostis JB, Goyal S. Radia-tion-induced heart disease: pathologic abnor-malities and putative.
Downloads
Published
Issue
Section
License
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal the right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors can enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
- Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) before and during the submission process, as it can lead to productive exchanges and earlier and greater citation of published work (See The Effect of Open Access).
How to Cite
