Non-ST Elevation Myocardial Infarction in Young Women with Diabetic Ketoacidosis

Authors

  • Novi Rahmawati a:1:{s:5:"en_US";s:130:"Residen Program Studi Kedokteran Spesialis Jantung dan Pembuluh Darah Universitas Brawijaya, RSUD Saiful Anwar, Malang, Jawa Timur";}
  • Indra Prasetya Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.
  • Andhika Prastya Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia.

DOI:

https://doi.org/10.11594/jk-risk.04.3.8

Keywords:

Diabetic Ketoacidosis, Non-ST Elevation Myocardial Infarction

Abstract

Diabetic ketoacidosis (DKA) is the primary acute metabolic complication of diabetes mellitus (DM), specifically type 2 DM. Individuals with acute coronary syndrome (ACS) have a twice-higher incidence compared to non-diabetic individuals. In people with DM, ACS is responsible for 75% of mortality. This case report investigates a 34-year-old female patient who presented at the Emergency Department of Saiful Anwar Malang Hospital with acute gastrointestinal symptoms of diarrhea and moderate to severe dehydration. Patients with a history of type 2 DM were first diagnosed at the age of 28. The laboratory tests indicated the presence of high blood sugar levels, metabolic acidosis, and ketone-positive. During DKA hydration management, patients have atypical angina with ECG changes from sinus tachycardia to episodic Total AV Block (TAVB) spontaneous termination, increased cardiac enzyme HS (high-sensitivity) Troponin I. Patients diagnosed with acute Non-elevated Segment ST Myocardial Infarction (NSTEMI) very high risk criteria. The patient performed an immediate invasive strategy and promptly identified stenosis in three coronary arteries, with the target lesion being in the Right Coronary Artery (RCA). Subsequently, a drug-eluting stent was implanted in the osteal to mid RCA. Efficient and timely management strategies that prioritize accuracy and simultaneous therapy for cases of DKA and NSTEMI to achieve optimal outcomes.

Downloads

Download data is not yet available.

References

International Diabetes Federation. IDF Diabetes Atlas 10th edition [Internet]. 2021. Available from: www.diabetesatlas.org

Khan MAB, Hashim MJ, King JK, Govender RD, Mustafa H, Kaabi J Al. Epidemiology of Type 2 diabetes - Global burden of disease and forecasted trends. J Epidemiol Glob Health. 2020 Mar 1;10(1):107–11. DOI: https://doi.org/10.2991/jegh.k.191028.001

Xie J, Wang M, Long Z, Ning H, Li J, Cao Y, et al. Global burden of type 2 diabetes in adolescents and young adults, 1990-2019: systematic analysis of the Global Burden of Disease Study 2019. BMJ. 2022 Dec 7;379:e072385. DOI: https://doi.org/10.1136/bmj-2022-072385

Nagarathna R, Bali P, Anand A, Srivastava V, Patil S, Sharma G, et al. Prevalence of Diabetes and Its Determinants in the Young Adults Indian Population-Call for Yoga Intervention. Front Endocrinol (Lausanne). 2020 Dec 11;11. DOI: https://doi.org/10.3389/fendo.2020.507064

Kitabchi AE, Umpierrez GE, Miles JM, Fisher JN. Hyperglycemic crises in adult patients with diabetes. In: Diabetes Care. 2009. p. 1335–43. DOI: https://doi.org/10.2337/dc09-9032

Babes EE, Bustea C, Behl T, Abdel-Daim MM, Nechifor AC, Stoicescu M, et al. Acute coronary syndromes in diabetic patients, outcome, revascularization, and antithrombotic therapy. Vol. 148, Biomedicine and Pharmacotherapy. Elsevier Masson s.r.l.; 2022. DOI: https://doi.org/10.1016/j.biopha.2022.112772

Collet JP, Thiele H, Barbato E, Bauersachs J, Dendale P, Edvardsen T, et al. 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Vol. 42, European Heart Journal. Oxford University Press; 2021. p. 1289–367.

Washburn RL, Mueller K, Kaur G, Moreno T, Moustaid‐moussa N, Ramalingam L, et al. C‐peptide as a therapy for type 1 diabetes mellitus. Vol. 9, Biomedicines. MDPI AG; 2021. p. 1–24. DOI: https://doi.org/10.3390/biomedicines9030270

Buzzetti R, Tuomi T, Mauricio D, Pietropaolo M, Zhou Z, Pozzilli P, et al. Management of latent autoimmune diabetes in adults: A consensus statement from an international expert panel. Diabetes. 2020 Oct 1;69(10):2037–47. DOI: https://doi.org/10.2337/dbi20-0017

Valkovicova T, Skopkova M, Stanik J, Gasperikova D. Novel insights into genetics and clinics of the HNF1A-MODY. Endocr Regul. 2019 Apr 1;53(2):110–34. DOI: https://doi.org/10.2478/enr-2019-0013

Fatriyadi Suwandi J, Isti Angraini D, Dinia Putri S, Mikrobiologi dan Parasitologi B, Kedokteran F, Lampung U, et al. Maturity Onset Diabetes of the Young (MODY): Diagnosa dan Tatalaksana. 2019. DOI: https://doi.org/10.23960/jkunila.v3i1.pp226-231

Perkumpulan Endokrinologi Indonesia. Petunjuk Praktis Terapi Insulin Pada Pasien Diabetes Melitus 2021. 2021.

Febrianto D, Hindariati E. Tata Laksana Ketoasidosis Diabetik pada Penderita Gagal Jantung. Jurnal Penyakit Dalam Indonesia. 2021 Apr 4;8(1):46. DOI: https://doi.org/10.7454/jpdi.v8i1.273

Dewata DGUB, Novida H, Aryati A. Profile of Diabetic Ketoacidosis Patients at Regional Public Hospital dr. Soetomo in 2017. Jurnal Berkala Epidemiologi. 2020;8(3). DOI: https://doi.org/10.20473/jbe.V8I32020.301-309

Ahmad R, Narwaria M, Singh A, Kumar S, Haque M. Detecting Diabetic Ketoacidosis with Infection: Combating a Life-Threatening Emergency with Practical Diagnostic Tools. Vol. 13, Diagnostics. Multidisciplinary Digital Publishing Institute (MDPI); 2023. DOI: https://doi.org/10.3390/diagnostics13142441

Miarta A, Zulfariansyah A. Tatalaksana Pasien Ketoasidosis Diabetikum yang Disertai Syok Sepsis. Anestesia dan Critical Care. 2019;37.

Perkumpulan Endokrinologi Indonesia. Tatalaksana Pasien dengan Hiperglikemia di Rumah Sakit. 2022.

Li L, Li G, Chen H, Feng Z, Zhang L, Chen L, et al. Role of Diabetes Mellitus in Acute Coronary Syndrome Patients with Heart Failure and Midrange Ejection Fraction Who Have Undergone Percutaneous Coronary Intervention: A 3-Year Case-Series Follow-Up Retrospective Study. Psychol Res Behav Manag. 2021;14:4931–44. DOI: https://doi.org/10.2147/DMSO.S339209

Kitabchi AE, Umpierrez GE, Murphy MB, Kreisberg RA. Hyperglycemic crises in adult patients with diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 2006 Dec;29(12):2739–48. DOI: https://doi.org/10.2337/dc06-9916

Angeli F, Reboldi G, Poltronieri C, Lazzari L, Sordi M, Garofoli M, et al. Hyperglycemia in acute coronary syndromes: From mechanisms to prognostic implications. Vol. 9, Therapeutic Advances in Cardiovascular Disease. 2015. p. 412–24. DOI: https://doi.org/10.1177/1753944715594528

Gandhi MJ, Suvarna TT. Cardiovascular Complications in Diabetic Ketoacidosis. Vol. 15, INT. J. DIAB. DEV. COUNTRIES. 1995.

Sheehan L, Calfas D, Candidate P. Cardiovascular Complications of Ketoacidosis [Internet]. Vol. 17. 2016. Available from: https://www.uspharmacist.com/article/cardiovascular-complications-of-ketoacidosis

Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023 Oct 7;44(38):3720–826.

Marx N, Federici M, Schütt K, Müller-Wieland D, Ajjan RA, Antunes MJ, et al. 2023 ESC Guidelines for the management of cardiovascular disease in patients with diabetes. Eur Heart J. 2023 Oct 14;44(39):4043–140.

Downloads

Published

2025-06-25

How to Cite

Rahmawati, N., Prasetya, I., & Prastya, A. (2025). Non-ST Elevation Myocardial Infarction in Young Women with Diabetic Ketoacidosis. Jurnal Klinik Dan Riset Kesehatan, 4(3), 237-248. https://doi.org/10.11594/jk-risk.04.3.8

Similar Articles

21-30 of 73

You may also start an advanced similarity search for this article.