Correlation Between Increased Uric Acid Levels and the Severity of Coronary Artery Stenosis in Patients with Chronic Coronary Syndrome
DOI:
https://doi.org/10.11594/jk-risk.05.2.5Keywords:
Urid acid, severity of coronady artery stenosis, chronic coronary syndromeAbstract
Coronary artery disease (CAD) remains the most common cause of death globally despite advancements in treatment. Uric acid (UA) has been associated with the development of cardiovascular events in patients with Chronic Coronary Syndrome (CCS). Several hypotheses suggest that UA exerts a negative impact on coronary arteries and/or increases the risk of major adverse cardiovascular events (MACE).
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References
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20. Ikramullah S, Hamid R, Fatima A, Chaudhry ZA, Tareen M, Ahmed F. Association between hyperuricemia and coronary artery disease severity among patients undergoing coronary angiography. Int J Health Sci (Qassim). 2023;7(S1):2368-2374. doi:10.53730/ijhs.v7nS1.14510
21. Ndrepepa G. Uric acid and cardiovascular disease. Clinica Chimica Acta. 2018;484:150-163. doi:10.1016/j.cca.2018.05.046
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23. Kimura Y, Yanagida T, Onda A, Tsukui D, Hosoyamada M, Kono H. Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. Arterioscler Thromb Vasc Biol. 2020;40(3):570-582. doi:10.1161/ATVBAHA.119.313224
24. Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V. Regulation of uric acid metabolism and excretion. Int J Cardiol. 2016;213:8-14. doi:10.1016/j.ijcard.2015.08.109
25. Li K, Li K, Yao Q, et al. The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor. Heliyon. 2023;9(5). doi:10.1016/j.heliyon.2023.e16097
26. Serum Uric Acid and Cardiovascular Mortality. http://jama.jamanetwork.com/
27. Holme I, Aastveit AH, Hammar N, Jungner I, Walldius G. Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417 734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). J Intern Med. 2009;266(6):558-570. doi:10.1111/j.1365-2796.2009.02133.x
28. Niskanen LK, Laaksonen DE, Nyyssönen K, et al. Uric Acid Level as a Risk Factor for Cardiovascular and All-Cause Mortality in Middle-Aged Men A Prospective Cohort Study. http://archinte.jamanetwork.com/
29. Meisinger C, Koenig W, Baumert J, Döring A. Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population the MONICA ORA cohort study. Arterioscler Thromb Vasc Biol. 2008;28(6):1186-1192. doi:10.1161/ATVBAHA.107.160184
30. Braga F, Pasqualetti S, Ferraro S, Panteghini M. Hyperuricemia as risk factor for coronary heart disease incidence and mortality in the general population: A systematic review and meta-analysis. Clin Chem Lab Med. 2016;54(1):7-15. doi:10.1515/cclm-2015-0523
31. Dai XM, Wei L, Ma LL, et al. Serum uric acid and its relationship with cardiovascular risk profile in Chinese patients with early-onset coronary artery disease. Clin Rheumatol. 2015;34(9):1605-1611. doi:10.1007/s10067-015-2878-1
32. von Lueder TG, Girerd N, Atar D, et al. Serum uric acid is associated with mortality and heart failure hospitalizations in patients with complicated myocardial infarction: findings from the High‐Risk Myocardial Infarction Database Initiative. Eur J Heart Fail. 2015;17(11):1144-1151. doi:10.1002/ejhf.419
33. Li M, Hu X, Fan Y, et al. Hyperuricemia and the risk for coronary heart disease morbidity and mortality a systematic review and dose-response meta-analysis. Sci Rep. 2016;6(1):19520. doi:10.1038/srep19520
34. Wang R, Song Y, Yan Y, Ding Z. Elevated serum uric acid and risk of cardiovascular or all-cause mortality in people with suspected or definite coronary artery disease: A meta-analysis. Atherosclerosis. 2016;254:193-199. doi:10.1016/j.atherosclerosis.2016.10.006
35. Kobayashi N, Asai K, Tsurumi M, et al. Impact of Accumulated Serum Uric Acid on Coronary Culprit Lesion Morphology Determined by Optical Coherence Tomography and Cardiac Outcomes in Patients with Acute Coronary Syndrome. Cardiology. 2018;141(4):190-198. doi:10.1159/000496053
36. Kimura Y, Yanagida T, Onda A, Tsukui D, Hosoyamada M, Kono H. Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. Arterioscler Thromb Vasc Biol. 2020;40(3):570-582. doi:10.1161/ATVBAHA.119.313224
37. Jun JE, Lee YB, Lee SE, et al. Elevated serum uric acid predicts the development of moderate coronary artery calcification independent of conventional cardiovascular risk factors. Atherosclerosis. 2018;272:233-239. doi:10.1016/j.atherosclerosis.2018.02.014
2. Global, Regional, and National Incidence, Prevalence, and Years Lived with Disability for 354 Diseases and Injuries for 195 Countries and Territories, 1990-2017: A Systematic Analysis for the Global Burden of Disease Study 2017.; 2018. https://github.com/ihmeuw/
3. Riset Kesehatan Dasar (Riskesdas). Badan Penelitian Dan Pengembangan Kesehatan Kementrian RI.; 2018.
4. Malakar AK, Choudhury D, Halder B, Paul P, Uddin A, Chakraborty S. A review on coronary artery disease, its risk factors, and therapeutics. J Cell Physiol. 2019;234(10):16812-16823. doi:10.1002/jcp.28350
5. Budaj A, Buechel RR, Alfonso Chiariello G, et al. Milan Milojevic 1 (Serbia). Torsten Doenst. 1. doi:10.1093/eurheartj/ehae177
6. Abdelrazek G, Yassin A, Elkhashab K. Correlation between global longitudinal strain and SYNTAX score in coronary artery disease evaluation. The Egyptian Heart Journal. 2020;72(1):22. doi:10.1186/s43044-020-00064-2
7. Liang L, Hou X, Bainey KR, et al. The association between hyperuricemia and coronary artery calcification development: A systematic review and meta-analysis. Clin Cardiol. 2019;42(11):1079-1086. doi:10.1002/clc.23266
8. Larsen TR, Gerke O, Diederichsen ACP, et al. The association between uric acid levels and different clinical manifestations of coronary artery disease. Coron Artery Dis. 2018;29(3):194-203. doi:10.1097/MCA.0000000000000593
9. Ekici B, Kütük U, Alhan A, Töre HF. The relationship between serum uric acid levels and angiographic severity of coronary heart disease. Kardiol Pol. 2015;73(7):533-538. doi:10.5603/KP.a2015.0024
10. Tabakcl MM, Gerin F, Sunbul M, et al. Relation of Plasma Fibrinogen Level with the Presence, Severity, and Complexity of Coronary Artery Disease. Clinical and Applied Thrombosis/Hemostasis. 2017;23(6):638-644. doi:10.1177/1076029616629210
11. Safarian H, Alidoosti M, Shafiee A, Salarifar M, Poorhosseini H, Nematipour E. The SYNTAX score can predict major adverse cardiac events following percutaneous coronary intervention. Heart Views. 2014;15(4):99. doi:10.4103/1995-705x.151081
12. Kakadiya J, Jagdish M, Kakadiya L. CAUSES, SYMPTOMS, PATHOPHYSIOLOGY AND DIAGNOSIS OF ATHEROSCLEROSIS-A REVIEW ADDRESS FOR CORRESPONDENCE. Vol 3.; 2009.
13. Jebari-Benslaiman S, Galicia-García U, Larrea-Sebal A, et al. Pathophysiology of Atherosclerosis. Int J Mol Sci. 2022;23(6). doi:10.3390/ijms23063346
14. Libby P, Professor of Medicine M, Bonow RO, et al. HEART DISEASE A TEXTBOOK OF CARDIOVASCULAR MEDICINE.; 2022. http://www.elsevier.com/permissions.
15. Bairey Merz CN, Shaw LJ, Reis SE, et al. Insights from the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE) study. Part II: Gender differences in presentation, diagnosis, and outcome with regard to gender-based pathophysiology of atherosclerosis and macrovascular and microvascular coronary disease. J Am Coll Cardiol. 2006;47(3 SUPPL.):S21-S29. doi:10.1016/j.jacc.2004.12.084
16. Lopes RD, Alexander KP, Stevens SR, et al. Initial Invasive Versus Conservative Management of Stable Ischemic Heart Disease in Patients With a History of Heart Failure or Left Ventricular Dysfunction: Insights From the ISCHEMIA Trial. Circulation. 2020;142(18):1725-1735. doi:10.1161/CIRCULATIONAHA.120.050304
17. Rozanski A, Miller RJH, Gransar H, et al. Benefit of Early Revascularization Based on Inducible Ischemia and Left Ventricular Ejection Fraction. J Am Coll Cardiol. 2022;80(3):202-215. doi:10.1016/j.jacc.2022.04.052
18. Chen CJ, Lü JM, Yao Q. Hyperuricemia-related diseases and xanthine oxidoreductase (XOR) inhibitors: An overview. Medical Science Monitor. 2016;22:2501-2512. doi:10.12659/MSM.899852
19. El Ridi R, Tallima H. Physiological functions and pathogenic potential of uric acid: A review. J Adv Res. 2017;8(5):487-493. doi:10.1016/j.jare.2017.03.003
20. Ikramullah S, Hamid R, Fatima A, Chaudhry ZA, Tareen M, Ahmed F. Association between hyperuricemia and coronary artery disease severity among patients undergoing coronary angiography. Int J Health Sci (Qassim). 2023;7(S1):2368-2374. doi:10.53730/ijhs.v7nS1.14510
21. Ndrepepa G. Uric acid and cardiovascular disease. Clinica Chimica Acta. 2018;484:150-163. doi:10.1016/j.cca.2018.05.046
22. Yu W, Cheng JD. Uric Acid and Cardiovascular Disease: An Update From Molecular Mechanism to Clinical Perspective. Front Pharmacol. 2020;11. doi:10.3389/fphar.2020.582680
23. Kimura Y, Yanagida T, Onda A, Tsukui D, Hosoyamada M, Kono H. Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. Arterioscler Thromb Vasc Biol. 2020;40(3):570-582. doi:10.1161/ATVBAHA.119.313224
24. Maiuolo J, Oppedisano F, Gratteri S, Muscoli C, Mollace V. Regulation of uric acid metabolism and excretion. Int J Cardiol. 2016;213:8-14. doi:10.1016/j.ijcard.2015.08.109
25. Li K, Li K, Yao Q, et al. The potential relationship of coronary artery disease and hyperuricemia: A cardiometabolic risk factor. Heliyon. 2023;9(5). doi:10.1016/j.heliyon.2023.e16097
26. Serum Uric Acid and Cardiovascular Mortality. http://jama.jamanetwork.com/
27. Holme I, Aastveit AH, Hammar N, Jungner I, Walldius G. Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417 734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). J Intern Med. 2009;266(6):558-570. doi:10.1111/j.1365-2796.2009.02133.x
28. Niskanen LK, Laaksonen DE, Nyyssönen K, et al. Uric Acid Level as a Risk Factor for Cardiovascular and All-Cause Mortality in Middle-Aged Men A Prospective Cohort Study. http://archinte.jamanetwork.com/
29. Meisinger C, Koenig W, Baumert J, Döring A. Uric acid levels are associated with all-cause and cardiovascular disease mortality independent of systemic inflammation in men from the general population the MONICA ORA cohort study. Arterioscler Thromb Vasc Biol. 2008;28(6):1186-1192. doi:10.1161/ATVBAHA.107.160184
30. Braga F, Pasqualetti S, Ferraro S, Panteghini M. Hyperuricemia as risk factor for coronary heart disease incidence and mortality in the general population: A systematic review and meta-analysis. Clin Chem Lab Med. 2016;54(1):7-15. doi:10.1515/cclm-2015-0523
31. Dai XM, Wei L, Ma LL, et al. Serum uric acid and its relationship with cardiovascular risk profile in Chinese patients with early-onset coronary artery disease. Clin Rheumatol. 2015;34(9):1605-1611. doi:10.1007/s10067-015-2878-1
32. von Lueder TG, Girerd N, Atar D, et al. Serum uric acid is associated with mortality and heart failure hospitalizations in patients with complicated myocardial infarction: findings from the High‐Risk Myocardial Infarction Database Initiative. Eur J Heart Fail. 2015;17(11):1144-1151. doi:10.1002/ejhf.419
33. Li M, Hu X, Fan Y, et al. Hyperuricemia and the risk for coronary heart disease morbidity and mortality a systematic review and dose-response meta-analysis. Sci Rep. 2016;6(1):19520. doi:10.1038/srep19520
34. Wang R, Song Y, Yan Y, Ding Z. Elevated serum uric acid and risk of cardiovascular or all-cause mortality in people with suspected or definite coronary artery disease: A meta-analysis. Atherosclerosis. 2016;254:193-199. doi:10.1016/j.atherosclerosis.2016.10.006
35. Kobayashi N, Asai K, Tsurumi M, et al. Impact of Accumulated Serum Uric Acid on Coronary Culprit Lesion Morphology Determined by Optical Coherence Tomography and Cardiac Outcomes in Patients with Acute Coronary Syndrome. Cardiology. 2018;141(4):190-198. doi:10.1159/000496053
36. Kimura Y, Yanagida T, Onda A, Tsukui D, Hosoyamada M, Kono H. Soluble Uric Acid Promotes Atherosclerosis via AMPK (AMP-Activated Protein Kinase)-Mediated Inflammation. Arterioscler Thromb Vasc Biol. 2020;40(3):570-582. doi:10.1161/ATVBAHA.119.313224
37. Jun JE, Lee YB, Lee SE, et al. Elevated serum uric acid predicts the development of moderate coronary artery calcification independent of conventional cardiovascular risk factors. Atherosclerosis. 2018;272:233-239. doi:10.1016/j.atherosclerosis.2018.02.014
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2026-02-25
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How to Cite
Lestari, D., & Satrijo, B. . (2026). Correlation Between Increased Uric Acid Levels and the Severity of Coronary Artery Stenosis in Patients with Chronic Coronary Syndrome. Jurnal Klinik Dan Riset Kesehatan, 5(2), 123-134. https://doi.org/10.11594/jk-risk.05.2.5
